Michael J. Fox

Stuart Little (voice)

Geena Davis

Mrs. Little

Hugh Laurie

Mr. Little

Jonathan Lipnicki

George Little

Nathan Lane

Snowbell (voice)

Chazz Palminteri

Smokey (voice)

Steve Zahn

Monty (voice)

Jim Doughan

Lucky (voice) / Officer Allen

David Alan Grier

Red (voice)

Bruno Kirby

Mr. Stout (voice)

Jennifer Tilly

Mrs. Stout (voice)

Stan Freberg

Race Announcer (voice)

Jeffrey Jones

Uncle Crenshaw

Connie Ray

Aunt Tina