Tom Hanks

Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry

Halle Berry

Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym

Jim Broadbent

Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2

Hugo Weaving

Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie

Jim Sturgess

Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law

배두나

Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute

Ben Whishaw

Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman

James D'Arcy

Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist

周迅

Talbot / Hotel Manager / Yoona-939 / Rose

Keith David

Kupaka / Joe Napier / An-kor Apis / Prescient

Susan Sarandon

Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess

Hugh Grant

Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief

David Gyasi

Autua / Lester Rey / Duophsyte

Robert Fyfe

Old Salty Dog / Mr. Meeks / Prescient 1